MSH works in Honduras through the Local Technical Assistance Unit for Health Project (ULAT II), the Leadership, Management and Governance Project (LMG), and the Salud Mesoamérica Initiative (SMI).

Through ULAT II, MSH supports the Ministry of Health and other partners to increase access to quality family planning and maternal and child health services, through health sector reform and decentralizing health services. ULAT strengthens the country's health system, improving health care access for underserved and vulnerable populations in the country. Among the project's accomplishments is the 2013 launch and roll-out of the new National Health Model.

The LMG project has provided technical assistance to the Ministry of Health to strengthen its management of contracts with local NGOs that are providing HIV prevention, education, and rapid testing services.

SMI, a public/private partnership, reduces health equity gaps faced by those living in extreme poverty in Mesoamérica. Through SMI, MSH provides technical assistance to improve access to quality health services for the poorest 20 percent of the country's population. This technical assistance focuses on expanding obstetric and neonatal care, newborn and child health, and family planning services.

USAID|PASCA LMG began providing technical assistance in Honduras in mid-2016 and worked in coordination with the Ministry of Health. This organization has a horizontal structure and does not have a single unit or benchmark for HIV. The project also worked in coordination with civil society organizations, USAID partners, and other stakeholders.

USAID|PASCA LMG contributed to the following key achievements in Honduras:

1. Adoption by the Ministry of Health of the Protocol for Victims of Sexual Violence, which focuses on access to Post Exposure Prophylaxis in cases of sexual violence, without excluding key populations living with HIV.
2. Dissemination of strategic information to national authorities through public forums as a key advocacy mechanism.