GMS’s third project year coincided with the evolution of the two major mechanisms defining GMS’s environment: the United States President’s Emergency Plan for AIDS Relief (PEPFAR) and the new funding model (NFM) of the Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund). At the same time, most Global Fund countries moved from the concept-note to the grant-making and grant-signature phases of the Global Fund’s new funding model. GMS provided critical support to 23 countries to complete this vital step in the new architecture, either by supporting new PRs with grant making, assisting country coordinating mechanisms (CCMs) to carry out their performance improvement plans to ensure eligibility for grant signature, or both. At the African regional level, GMS collaborated with other technical-support providers to advance governance reform of the two African delegations to the Global Fund Board and with the Global Fund Secretariat to advance analysis and action to improve funds absorption among 10 West and Central African francophone countries. This last activity aligned with a constellation of other collaboration activities with the Global Fund Secretariat to improve risk management, funds absorption, and effective grant and subrecipient (SR) management and oversight, which were crowned by GMS’s handover to the Global Fund of the PR Management Dashboard, for which demand increases monthly. Under the leadership of and with guidance from the USAID multilateral team, GMS’s project year 3 was a year for tactical implementation to support the Global Fund’s new architecture.