Pre-Extensively Drug-Resistant Tuberculosis among Multidrug-Resistant Tuberculosis Patients in Ethiopia: A Laboratory-based Surveillance Study
Pre-Extensively Drug-Resistant Tuberculosis among Multidrug-Resistant Tuberculosis Patients in Ethiopia: A Laboratory-based Surveillance Study
By: Getu Diriba, Ayinalem Alemu, Habteyes Hailu Tola, Bazezew Yenew, Misikir Amare, Kirubel Eshetu, Waganeh Sinshaw, Yeshiwork Abebaw, Abyot Meaza, Getachew Seid, Shewki Moga , Betselot Zerihun, Melak Getu, Biniyam Dagne, Hilina Mollalign, Mengistu Tadesse, Bedo Buta, Niguse Wordofa, Ephrem Alemu, Ashenafi Erresso, Michael Hailu, Zigba Tefera, Amanuel Wondimu, Tegegn Belhu, Dinka Fekadu Gamtesa, Muluwork Getahun, Abebaw Kebede, Saro Abdela
Publication: International Journal of Infectious Diseases; 30 Aug 2022;5:39-43. https://doi.org/10.1016/j.ijregi.2022.08.012
Abstract
The rise of drug-resistant tuberculosis (DR-TB) has presented a substantial challenge to the national tuberculosis (TB) control program in Ethiopia. Understanding the epidemiology of pre-extensively drug-resistant tuberculosis (pre-XDR-TB) could help clinicians to adapt MDR-TB treatment regimens at an earlier stage. This study aimed to assess second-line anti-TB drug resistance among MDR-TB patients in Ethiopia using routine laboratory-based data.
Laboratory-based cross-sectional data were collected from the national TB reference laboratory and seven regional tuberculosis culture laboratories in Ethiopia from July 2019 to March 2022. The required data, such as drug-susceptibility testing (DST) results and sociodemographics, were collected on a structured checklist from laboratory registration books and electronic databases. Data were entered into a Microsoft Excel spreadsheet and analyzed using SPSS version 23. Descriptive statistics were performed to show the distribution and magnitude of drug resistance.