Expansion of prevention of mother-to-child transmission in resource-limited settings remains a challenge.
In many countries, most HIV-exposed infants do not benefit from PMTCT programs, which results in a 30% or more transmission rate.
Vertically infected infants not diagnosed in the context of PMTCT are rarely diagnosed until symptomatic with HIV, resulting in increased morbidity and mortality.
Infant and pediatric testing programs are needed until PMTCT challenges are overcome or universal treatment of HIV-infected pregnant women becomes the norm.