The three-year Care and Treatment for Sustained Support (CaTSS) project was implemented by MSH in close partnership with the Government of Nigeria and local partners. The project was funded by the US President’s Emergency Plan for AIDS Relief (PEPFAR) through the USAID and brought about significant improvements in case finding and treatment outcomes for HIV/AIDS and tuberculosis (TB) in the North West Nigeria region. To support self-reliance and sustainability of the gains, the project implemented a peer mentorship program that transferred critical HIV patient and program management skills to frontline health workers and state ministries of health. This initiative enhanced the capacity of the host state government to both manage and lead HIV/AIDS and TB programs and provide sustainable, integrated, quality HIV/AIDS and TB services in their health facilities.